Tow-Photon Polymerization (2PP) enables 3D microsystems for Pharmatechnology

Two-photon polymerization(2PP) is a process for three-dimensional (3D) micro-and Nano structuring based on the locally controlled curing of liquid precursors (light-sensitive resins) by photochemical triggered polymerization. In this decade, will be hearing a lot about this technic being applied to pharmaceutical applications like fabricating 3D microchannels for nanoparticle precipitation, nano-porous membranes and scaffolds for cell culturing, biomimetic organ-on-chip systems. This paper presents 2pp applied microsystems for continuously generating lipid nanoparticles which are one of the most important drug carrier system. The most important advantages of 2pp is manufacturing 3D shapes that is not possible with lithographic micro and nano fabrication technologies. Also, it will be shown how 2pp fabricated microchannel can be integrated with continuous size measurement by flowDLS for the feed-back controlled generation of nanoparticles.