SDS affects the physicochemical properties of PVA-stabilized solid triglyceride nanoparticles

Solid triglyceride nanoparticles are under intensive investigation as drug delivery systems. In the solid state, triglycerides exist in three polymorphic modifications which differ from each other in their physicochemical properties. Thus, it is particularly important to know the influence of parameters affecting the polymorphic behavior of the solid triglyceride nanoparticles to get a stable product with defined physicochemical properties over an appropriate storage time. This study investigated the effect of subsequent addition of SDS to tripalmitin nanoparticles, which had been stabilized with partially hydrolyzed poly(vinyl alcohol) (PVA). The polymorphic behavior was characterized with DSC and X-ray diffraction over a storage time of 28 d at 20 °C. A faster transition into more stable polymorphic modifications was observed after the addition of SDS to the nanoparticles.