PEG-ylated parenteral Nanoemulsions as prospective Carriers for enhanced Brain Delivery with Diazepam as a Model Drug - Physicochemical Characterisation

Parenteral nanoemulsions are regarded as biocompatible drug delivery systems for lypophilic drugs. When it comes to delivering actives to the brain as a target site, prolonged circulation time is desirable. The objective of this study was to conduct physicochemical characterization of PEGylated nanoemulsions as prospective carriers for enhanced brain delivery, using diazepam as a model active substance for brain targeting. Nanoemulsions were prepared by high pressure homogenization method and characterized regarding droplet size, zeta potential, pH, conductivity, viscosity and in vitro release profile. PEG2000-DSPE and PEG5000-DPPE were used for PEGylation. All the formulations were autoclaved and stored at room temperature. After 2 months there were no significant changes in physicochemical parameters in autoclaved formulations which rendered them as good potential templates to incorporate drugs for brain targeted delivery.