Hydrogels based on polymerized ionic Liquids as innovative Drug Carriers in controllable and individualized Dosage Forms

Novel Polymerized Ionic Liquids (PILs)-based Hydrogels as Innovative Drug Delivery Systems are presented. The embedding of drugs in hydrogels enables the “smart” delivery of bioactive molecules from drugs for an oral route of administration. Therefore, a high mechanical strength as well as a favorable pH-dependent swelling behavior is required which is shown in this study. A mechanical compression of PILs-based hydrogels up to 98.5% and a high swelling behavior of poly(VEImBr) hydrogels in a solution with a high pH value is achieved. A significant lower swelling is achieved in a solution with a lower pH value.